Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC103156621E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (327 aa)    
Predicted Functional Partners:
LOC103142753
Uncharacterized protein; Belongs to the synuclein family.
    
 0.928
cacybp
Calcyclin binding protein.
    
 
 0.920
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 
 0.871
ENSPFOP00000000489
Synuclein, alpha interacting protein.
    
 0.839
ENSPFOP00000014388
Ubiquitin-conjugating enzyme E2 variant 2.
    
   0.823
gapdhs
Glyceraldehyde-3-phosphate dehydrogenase.
   
 
 0.814
gapdh
Glyceraldehyde-3-phosphate dehydrogenase.
   
 
 0.814
dld
Dihydrolipoyl dehydrogenase.
    
   0.805
UBE2N
Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.773
LOC103129309
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.773
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
Server load: low (8%) [HD]