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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103129193MCL1 apoptosis regulator, BCL2 family member b. (276 aa)    
Predicted Functional Partners:
BAX
BCL2 associated X, apoptosis regulator.
    
 0.988
huwe1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
    
 
 0.952
LOC103150954
Zgc:153993.
    
 
 0.949
becn1
Beclin 1, autophagy related.
    
 0.942
ENSPFOP00000003293
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
     
 0.933
LOC103150443
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
     
 0.922
LOC103150441
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
     
 0.903
bad
BCL2 associated agonist of cell death b.
   
 0.847
apaf1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.847
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.823
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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