Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tbk1TANK-binding kinase 1. (721 aa)    
Predicted Functional Partners:
ENSPFOP00000002885
Interferon regulatory factor 3.
    
 0.999
sting1
Transmembrane protein 173.
   
 0.998
traf3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.997
tank
TRAF family member-associated NFKB activator.
   
 0.996
optn
Optineurin.
   
 0.995
sqstm1
Sequestosome 1.
    
 0.995
irf7
Interferon regulatory factor 7.
   
 0.988
ENSPFOP00000026086
SKICH domain-containing protein.
    
 0.988
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.970
LOC103140625
V-rel avian reticuloendotheliosis viral oncogene homolog A.
   
 0.958
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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