Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSPFOP00000002298Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (339 aa)    
Predicted Functional Partners:
ENSPFOP00000012330
Protein kinase, cAMP-dependent, regulatory, type I, beta.
 
 
 0.994
prkar1a
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b.
 
 
 0.990
ENSPFOP00000020312
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.987
smo
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.984
prkar2b
Protein kinase cAMP-dependent type II regulatory subunit beta.
   
 0.983
prkar2a
Protein kinase, cAMP-dependent, regulatory, type II, alpha A.
   
 0.983
LOC103130288
Protein kinase, cAMP-dependent, regulatory, type II, alpha, B.
   
 0.983
ENSPFOP00000019415
GLI family zinc finger 3.
    
 0.968
ENSPFOP00000005174
Uncharacterized protein.
    
 0.966
gli1
GLI family zinc finger 1.
    
 0.966
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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