Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ENSPFOP00000003602Insulin receptor substrate 4a. (1145 aa)    
Predicted Functional Partners:
grb2
Growth factor receptor-bound protein 2b.
    
 0.991
insr
Tyrosine-protein kinase receptor.
    
 0.980
LOC103138516
Tyrosine-protein kinase receptor.
    
 0.980
ENSPFOP00000015872
Tyrosine-protein kinase receptor.
    
 0.980
ENSPFOP00000019308
Tyrosine-protein kinase receptor.
    
 0.980
mtor
Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.
    
 0.967
LOC103145153
Suppressor of cytokine signaling 3.
    
 0.946
socs3
Suppressor of cytokine signaling 3a.
    
 0.946
LOC103139099
Tyrosine-protein phosphatase non-receptor type.
    
 0.933
ikbkb
Inhibitor of nuclear factor kappa B kinase subunit beta.
    
 0.931
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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