Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC103139421Tight junction protein 1a; Belongs to the MAGUK family. (1775 aa)    
Predicted Functional Partners:
gja1
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
   
 0.998
LOC103155563
Occludin a.
   
 0.997
ENSPFOP00000008931
F11 receptor, tandem duplicate 1.
   
 0.993
ENSPFOP00000018276
Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family.
   
0.990
ENSPFOP00000003931
Afadin, adherens junction formation factor a.
   
 0.989
ENSPFOP00000029045
PDZ domain-containing protein.
   
 0.980
LOC103149554
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
 0.971
ctnna1
Catenin (cadherin-associated protein), alpha 1.
   
 0.957
ENSPFOP00000005687
Catenin (cadherin-associated protein), alpha 2.
   
 0.957
CLDN8
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
 0.954
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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