STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC103148476Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (124 aa)    
Predicted Functional Partners:
cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.985
mdm2
MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.
  
 0.985
LOC103134991
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.981
ccnd1
Cyclin D1; Belongs to the cyclin family.
    
 0.974
ENSPFOP00000000206
Cyclin D2, b; Belongs to the cyclin family.
    
 0.972
LOC103155804
Cyclin D2, a; Belongs to the cyclin family.
    
 0.972
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.970
ENSPFOP00000000691
Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily.
    
 0.963
ENSPFOP00000000348
Cyclin D3; Belongs to the cyclin family.
    
 0.959
ENSPFOP00000011405
Cyclin Dx; Belongs to the cyclin family.
    
 0.958
Your Current Organism:
Poecilia formosa
NCBI taxonomy Id: 48698
Other names: Amazon molly, Limia formosa, Mollienesia formosa, P. formosa
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