STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSPLAP00000001188BHLH domain-containing protein. (168 aa)    
Predicted Functional Partners:
ENSPLAP00000010547
Link domain-containing protein.
     
 0.730
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.651
ENSPLAP00000029617
Twist family bHLH transcription factor 1a.
  
 
 
0.647
LOC106958149
BHLH domain-containing protein.
    
 
 0.626
tcf12
Transcription factor 12.
    
 
 0.624
LOC106938010
V-rel avian reticuloendotheliosis viral oncogene homolog A.
   
 
 0.561
relb
V-rel avian reticuloendotheliosis viral oncogene homolog B.
   
 
 0.561
REL
REL proto-oncogene, NF-kB subunit.
   
 
 0.561
LOC106959275
Transcription factor 3b.
    
 
 0.555
ENSPLAP00000010677
Uncharacterized protein.
    
 
 0.555
Your Current Organism:
Poecilia latipinna
NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.