mdk protein (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

mdk

Midkine b. (98 aa)

Predicted Functional Partners:

LOC106934444

0.857

ENSPLAP00000011515

0.813

LOC106954623

0.813

LOC106941359

0.714

egf

0.693

LOC106950474

0.688

tp53

0.680

met

0.671

LOC106949456

0.671

mst1r

0.671

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000011515	LOC106934444	ENSPLAP00000011515	ENSPLAP00000005419	ALK receptor tyrosine kinase.	Uncharacterized protein.	0.689
ENSPLAP00000011515	LOC106941359	ENSPLAP00000011515	ENSPLAP00000016783	ALK receptor tyrosine kinase.	Mechanistic target of rapamycin kinase.	0.432
ENSPLAP00000011515	mdk	ENSPLAP00000011515	ENSPLAP00000001520	ALK receptor tyrosine kinase.	Midkine b.	0.813
ENSPLAP00000011515	tp53	ENSPLAP00000011515	ENSPLAP00000022694	ALK receptor tyrosine kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.555
LOC106934444	ENSPLAP00000011515	ENSPLAP00000005419	ENSPLAP00000011515	Uncharacterized protein.	ALK receptor tyrosine kinase.	0.689
LOC106934444	LOC106949456	ENSPLAP00000005419	ENSPLAP00000030032	Uncharacterized protein.	Macrophage stimulating 1 receptor a.	0.649
LOC106934444	LOC106954623	ENSPLAP00000005419	ENSPLAP00000031222	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.689
LOC106934444	mdk	ENSPLAP00000005419	ENSPLAP00000001520	Uncharacterized protein.	Midkine b.	0.857
LOC106934444	met	ENSPLAP00000005419	ENSPLAP00000026056	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.649
LOC106934444	mst1r	ENSPLAP00000005419	ENSPLAP00000030460	Uncharacterized protein.	Macrophage stimulating 1 receptor b.	0.649
LOC106941359	ENSPLAP00000011515	ENSPLAP00000016783	ENSPLAP00000011515	Mechanistic target of rapamycin kinase.	ALK receptor tyrosine kinase.	0.432
LOC106941359	LOC106949456	ENSPLAP00000016783	ENSPLAP00000030032	Mechanistic target of rapamycin kinase.	Macrophage stimulating 1 receptor a.	0.433
LOC106941359	LOC106954623	ENSPLAP00000016783	ENSPLAP00000031222	Mechanistic target of rapamycin kinase.	Tyrosine-protein kinase receptor.	0.432
LOC106941359	egf	ENSPLAP00000016783	ENSPLAP00000017455	Mechanistic target of rapamycin kinase.	Epidermal growth factor.	0.685
LOC106941359	mdk	ENSPLAP00000016783	ENSPLAP00000001520	Mechanistic target of rapamycin kinase.	Midkine b.	0.714
LOC106941359	met	ENSPLAP00000016783	ENSPLAP00000026056	Mechanistic target of rapamycin kinase.	MET proto-oncogene, receptor tyrosine kinase.	0.501
LOC106941359	mst1r	ENSPLAP00000016783	ENSPLAP00000030460	Mechanistic target of rapamycin kinase.	Macrophage stimulating 1 receptor b.	0.433
LOC106941359	tp53	ENSPLAP00000016783	ENSPLAP00000022694	Mechanistic target of rapamycin kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.970
LOC106949456	LOC106934444	ENSPLAP00000030032	ENSPLAP00000005419	Macrophage stimulating 1 receptor a.	Uncharacterized protein.	0.649
LOC106949456	LOC106941359	ENSPLAP00000030032	ENSPLAP00000016783	Macrophage stimulating 1 receptor a.	Mechanistic target of rapamycin kinase.	0.433