Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pidd1P53-induced death domain protein 1. (940 aa)    
Predicted Functional Partners:
casp2
Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.997
atm
ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.963
ENSPLAP00000029102
Uncharacterized protein.
   
 0.928
ripk1
Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.
   
 0.892
wdr90
WD repeat domain 90.
    
 0.874
ENSPLAP00000014192
NDK domain-containing protein.
   
 0.867
tonsl
Tonsoku-like, DNA repair protein.
  
 0.855
LOC106940357
CASP2 and RIPK1 domain containing adaptor with death domain.
     
  0.849
lrguk
Leucine-rich repeats and guanylate kinase domain containing.
   
 0.848
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.848
Your Current Organism:
Poecilia latipinna
NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly
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