Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
crebbpCREB binding protein a. (2427 aa)    
Predicted Functional Partners:
ENSPLAP00000013662
E1A binding protein p300 b.
  
0.999
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.997
LOC106939464
Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.
    
 0.993
LOC106961570
Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.
    
 0.993
sp1
Sp1 transcription factor.
   
 0.991
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.978
lef1
Lymphoid enhancer-binding factor 1.
    
 0.974
foxm1
Forkhead box M1.
    
 0.970
creb1
Uncharacterized protein.
    
 0.969
carm1
Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
    
 0.969
Your Current Organism:
Poecilia latipinna
NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly
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