OTUB2 protein (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

OTUB2

OTU deubiquitinase, ubiquitin aldehyde binding 2. (249 aa)

Predicted Functional Partners:

LOC106953803

0.883

ube2n

0.883

traf3

0.832

traf6

0.826

tp53

0.808

foxm1

0.769

washc3

0.764

usp8

0.757

rps27a

0.744

rnf128

0.721

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106953803	OTUB2	ENSPLAP00000000428	ENSPLAP00000001979	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	OTU deubiquitinase, ubiquitin aldehyde binding 2.	0.883
LOC106953803	rps27a	ENSPLAP00000000428	ENSPLAP00000025723	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ribosomal protein S27a.	0.967
LOC106953803	tp53	ENSPLAP00000000428	ENSPLAP00000022694	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.819
LOC106953803	traf3	ENSPLAP00000000428	ENSPLAP00000008244	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.779
LOC106953803	traf6	ENSPLAP00000000428	ENSPLAP00000026462	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.987
LOC106953803	ube2n	ENSPLAP00000000428	ENSPLAP00000012140	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.900
OTUB2	LOC106953803	ENSPLAP00000001979	ENSPLAP00000000428	OTU deubiquitinase, ubiquitin aldehyde binding 2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.883
OTUB2	foxm1	ENSPLAP00000001979	ENSPLAP00000009234	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Forkhead box M1.	0.769
OTUB2	rnf128	ENSPLAP00000001979	ENSPLAP00000000900	OTU deubiquitinase, ubiquitin aldehyde binding 2.	RING-type domain-containing protein.	0.721
OTUB2	rps27a	ENSPLAP00000001979	ENSPLAP00000025723	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Ribosomal protein S27a.	0.744
OTUB2	tp53	ENSPLAP00000001979	ENSPLAP00000022694	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.808
OTUB2	traf3	ENSPLAP00000001979	ENSPLAP00000008244	OTU deubiquitinase, ubiquitin aldehyde binding 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.832
OTUB2	traf6	ENSPLAP00000001979	ENSPLAP00000026462	OTU deubiquitinase, ubiquitin aldehyde binding 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.826
OTUB2	ube2n	ENSPLAP00000001979	ENSPLAP00000012140	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.883
OTUB2	usp8	ENSPLAP00000001979	ENSPLAP00000015313	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.757
OTUB2	washc3	ENSPLAP00000001979	ENSPLAP00000024320	OTU deubiquitinase, ubiquitin aldehyde binding 2.	WASH complex subunit 3.	0.764
foxm1	OTUB2	ENSPLAP00000009234	ENSPLAP00000001979	Forkhead box M1.	OTU deubiquitinase, ubiquitin aldehyde binding 2.	0.769
foxm1	tp53	ENSPLAP00000009234	ENSPLAP00000022694	Forkhead box M1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.683
rnf128	OTUB2	ENSPLAP00000000900	ENSPLAP00000001979	RING-type domain-containing protein.	OTU deubiquitinase, ubiquitin aldehyde binding 2.	0.721
rnf128	tp53	ENSPLAP00000000900	ENSPLAP00000022694	RING-type domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.764