Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
supt6hTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1600 aa)    
Predicted Functional Partners:
IWS1
Interacts with SUPT6H, CTD assembly factor 1.
   
 0.999
supt5h
Transcription elongation factor SPT5.
   
 0.998
polr2a
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 0.997
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.991
ssrp1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 0.988
ctr9
CTR9 homolog, Paf1/RNA polymerase II complex component.
  
 0.983
supt4h1
Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.
    
 0.982
ENSPLAP00000031114
FCP1 homology domain-containing protein.
     
 0.981
polr2c
Polymerase (RNA) II (DNA directed) polypeptide C.
   
 0.980
POLR2E
RNA polymerase II subunit E.
    
 0.978
Your Current Organism:
Poecilia latipinna
NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly
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