pten protein (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106938218	LOC106941461	ENSPLAP00000017585	ENSPLAP00000015446	SH2 domain-containing protein.	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	0.901
LOC106938218	LOC106947213	ENSPLAP00000017585	ENSPLAP00000023607	SH2 domain-containing protein.	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	0.900
LOC106938218	LOC106954316	ENSPLAP00000017585	ENSPLAP00000009233	SH2 domain-containing protein.	Uncharacterized protein.	0.902
LOC106938218	LOC106958016	ENSPLAP00000017585	ENSPLAP00000012355	SH2 domain-containing protein.	Inositol polyphosphate-4-phosphatase type I Ab.	0.902
LOC106938218	inpp4b	ENSPLAP00000017585	ENSPLAP00000014104	SH2 domain-containing protein.	Inositol polyphosphate-4-phosphatase type II B.	0.903
LOC106938218	pik3c3	ENSPLAP00000017585	ENSPLAP00000030684	SH2 domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.816
LOC106938218	pik3r3	ENSPLAP00000017585	ENSPLAP00000012775	SH2 domain-containing protein.	Uncharacterized protein.	0.901
LOC106938218	pten	ENSPLAP00000017585	ENSPLAP00000004864	SH2 domain-containing protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.946
LOC106941461	LOC106938218	ENSPLAP00000015446	ENSPLAP00000017585	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	SH2 domain-containing protein.	0.901
LOC106941461	LOC106947213	ENSPLAP00000015446	ENSPLAP00000023607	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	0.901
LOC106941461	LOC106954316	ENSPLAP00000015446	ENSPLAP00000009233	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Uncharacterized protein.	0.902
LOC106941461	LOC106958016	ENSPLAP00000015446	ENSPLAP00000012355	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Inositol polyphosphate-4-phosphatase type I Ab.	0.902
LOC106941461	inpp4b	ENSPLAP00000015446	ENSPLAP00000014104	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Inositol polyphosphate-4-phosphatase type II B.	0.904
LOC106941461	pik3c3	ENSPLAP00000015446	ENSPLAP00000030684	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.816
LOC106941461	pik3r3	ENSPLAP00000015446	ENSPLAP00000012775	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Uncharacterized protein.	0.901
LOC106941461	pten	ENSPLAP00000015446	ENSPLAP00000004864	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.946
LOC106947213	LOC106938218	ENSPLAP00000023607	ENSPLAP00000017585	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	SH2 domain-containing protein.	0.900
LOC106947213	LOC106941461	ENSPLAP00000023607	ENSPLAP00000015446	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	0.901
LOC106947213	LOC106954316	ENSPLAP00000023607	ENSPLAP00000009233	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	Uncharacterized protein.	0.901
LOC106947213	LOC106958016	ENSPLAP00000023607	ENSPLAP00000012355	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha).	Inositol polyphosphate-4-phosphatase type I Ab.	0.902