sost protein (Poecilia latipinna) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

sost

Sclerostin. (230 aa)

Predicted Functional Partners:

LOC106954095

0.989

ENSPLAP00000023467

0.989

sp7

0.728

LOC106957301

0.719

LOC106957415

0.695

mapk1

0.695

mapk7

0.695

vrk3

0.663

LOC106949137

0.645

dkk1

0.642

Your Current Organism:

Poecilia latipinna

NCBI taxonomy Id: 48699
Other names: Mollienesia latipinna, P. latipinna, sailfin molly

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPLAP00000023467	LOC106954095	ENSPLAP00000023467	ENSPLAP00000014136	Uncharacterized protein.	Low density lipoprotein receptor-related protein 6.	0.901
ENSPLAP00000023467	dkk1	ENSPLAP00000023467	ENSPLAP00000009481	Uncharacterized protein.	TNFR-Cys domain-containing protein.	0.997
ENSPLAP00000023467	sost	ENSPLAP00000023467	ENSPLAP00000006764	Uncharacterized protein.	Sclerostin.	0.989
LOC106949137	LOC106957301	ENSPLAP00000010518	ENSPLAP00000018469	Cathepsin K; Belongs to the peptidase C1 family.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.819
LOC106949137	sost	ENSPLAP00000010518	ENSPLAP00000006764	Cathepsin K; Belongs to the peptidase C1 family.	Sclerostin.	0.645
LOC106949137	sp7	ENSPLAP00000010518	ENSPLAP00000028354	Cathepsin K; Belongs to the peptidase C1 family.	Sp7 transcription factor.	0.722
LOC106954095	ENSPLAP00000023467	ENSPLAP00000014136	ENSPLAP00000023467	Low density lipoprotein receptor-related protein 6.	Uncharacterized protein.	0.901
LOC106954095	dkk1	ENSPLAP00000014136	ENSPLAP00000009481	Low density lipoprotein receptor-related protein 6.	TNFR-Cys domain-containing protein.	0.997
LOC106954095	sost	ENSPLAP00000014136	ENSPLAP00000006764	Low density lipoprotein receptor-related protein 6.	Sclerostin.	0.989
LOC106957301	LOC106949137	ENSPLAP00000018469	ENSPLAP00000010518	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Cathepsin K; Belongs to the peptidase C1 family.	0.819
LOC106957301	dkk1	ENSPLAP00000018469	ENSPLAP00000009481	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.775
LOC106957301	sost	ENSPLAP00000018469	ENSPLAP00000006764	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Sclerostin.	0.719
LOC106957301	sp7	ENSPLAP00000018469	ENSPLAP00000028354	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	Sp7 transcription factor.	0.719
LOC106957415	mapk1	ENSPLAP00000015746	ENSPLAP00000016708	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.900
LOC106957415	sost	ENSPLAP00000015746	ENSPLAP00000006764	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Sclerostin.	0.695
LOC106957415	vrk3	ENSPLAP00000015746	ENSPLAP00000027611	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	VRK serine/threonine kinase 3.	0.501
dkk1	ENSPLAP00000023467	ENSPLAP00000009481	ENSPLAP00000023467	TNFR-Cys domain-containing protein.	Uncharacterized protein.	0.997
dkk1	LOC106954095	ENSPLAP00000009481	ENSPLAP00000014136	TNFR-Cys domain-containing protein.	Low density lipoprotein receptor-related protein 6.	0.997
dkk1	LOC106957301	ENSPLAP00000009481	ENSPLAP00000018469	TNFR-Cys domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.775
dkk1	sost	ENSPLAP00000009481	ENSPLAP00000006764	TNFR-Cys domain-containing protein.	Sclerostin.	0.642