Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lig3DNA ligase. (998 aa)    
Predicted Functional Partners:
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1.
   
 0.999
polb
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
  
 0.998
pnkp
Polynucleotide kinase 3'-phosphatase.
   
 0.997
xrcc6
X-ray repair complementing defective repair in Chinese hamster cells 6.
   
 0.994
tdp1
Tyrosyl-DNA phosphodiesterase 1.
   
 
 0.994
ENSPMEP00000026639
Uncharacterized protein.
    
 
 0.991
parp2
Poly [ADP-ribose] polymerase.
   
 
 0.979
ENSPMEP00000021338
Si:ch1073-75f15.2.
   
 0.957
poll
Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.
  
 0.954
parp1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 
 0.936
Your Current Organism:
Poecilia mexicana
NCBI taxonomy Id: 48701
Other names: shortfin molly
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.