| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LOC106904253 | LOC106922722 | ENSPMEP00000026488 | ENSPMEP00000021189 | GTP cyclohydrolase 2. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.404 |
| LOC106904253 | LOC106927534 | ENSPMEP00000026488 | ENSPMEP00000024903 | GTP cyclohydrolase 2. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.404 |
| LOC106904253 | adss1 | ENSPMEP00000026488 | ENSPMEP00000004242 | GTP cyclohydrolase 2. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.404 |
| LOC106904253 | gch1 | ENSPMEP00000026488 | ENSPMEP00000013882 | GTP cyclohydrolase 2. | GTP cyclohydrolase 1. | 0.921 |
| LOC106904253 | itpa | ENSPMEP00000026488 | ENSPMEP00000001664 | GTP cyclohydrolase 2. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.970 |
| LOC106913894 | LOC106918883 | ENSPMEP00000004979 | ENSPMEP00000011360 | 5'-nucleotidase, cytosolic IAb. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.904 |
| LOC106913894 | LOC106922722 | ENSPMEP00000004979 | ENSPMEP00000021189 | 5'-nucleotidase, cytosolic IAb. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.947 |
| LOC106913894 | LOC106927534 | ENSPMEP00000004979 | ENSPMEP00000024903 | 5'-nucleotidase, cytosolic IAb. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.918 |
| LOC106913894 | adss1 | ENSPMEP00000004979 | ENSPMEP00000004242 | 5'-nucleotidase, cytosolic IAb. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.918 |
| LOC106913894 | atic | ENSPMEP00000004979 | ENSPMEP00000000353 | 5'-nucleotidase, cytosolic IAb. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.964 |
| LOC106913894 | gmps | ENSPMEP00000004979 | ENSPMEP00000011260 | 5'-nucleotidase, cytosolic IAb. | Guanine monophosphate synthase. | 0.962 |
| LOC106913894 | hprt1 | ENSPMEP00000004979 | ENSPMEP00000007942 | 5'-nucleotidase, cytosolic IAb. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.970 |
| LOC106913894 | itpa | ENSPMEP00000004979 | ENSPMEP00000001664 | 5'-nucleotidase, cytosolic IAb. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.966 |
| LOC106918883 | LOC106913894 | ENSPMEP00000011360 | ENSPMEP00000004979 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 5'-nucleotidase, cytosolic IAb. | 0.904 |
| LOC106918883 | LOC106922722 | ENSPMEP00000011360 | ENSPMEP00000021189 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.985 |
| LOC106918883 | LOC106927534 | ENSPMEP00000011360 | ENSPMEP00000024903 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.985 |
| LOC106918883 | adss1 | ENSPMEP00000011360 | ENSPMEP00000004242 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.985 |
| LOC106918883 | atic | ENSPMEP00000011360 | ENSPMEP00000000353 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.965 |
| LOC106918883 | gmps | ENSPMEP00000011360 | ENSPMEP00000011260 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Guanine monophosphate synthase. | 0.996 |
| LOC106918883 | hprt1 | ENSPMEP00000011360 | ENSPMEP00000007942 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.965 |