itpa protein (Poecilia mexicana) - STRING interaction network

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itpa

Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (195 aa)

Predicted Functional Partners:

nme7

0.981

nme6

0.980

nme3

0.971

LOC106931198

0.971

LOC106927218

0.971

LOC106918744

0.971

tpmt

0.968

atic

0.959

gmps

0.956

adss1

0.955

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106918744	LOC106927218	ENSPMEP00000034951	ENSPMEP00000030216	NDK domain-containing protein; Belongs to the NDK family.	Nucleoside diphosphate kinase.	0.901
LOC106918744	LOC106931198	ENSPMEP00000034951	ENSPMEP00000016366	NDK domain-containing protein; Belongs to the NDK family.	Nucleoside diphosphate kinase.	0.958
LOC106918744	itpa	ENSPMEP00000034951	ENSPMEP00000001664	NDK domain-containing protein; Belongs to the NDK family.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.971
LOC106918744	nme3	ENSPMEP00000034951	ENSPMEP00000014874	NDK domain-containing protein; Belongs to the NDK family.	Nucleoside diphosphate kinase.	0.902
LOC106918744	nme6	ENSPMEP00000034951	ENSPMEP00000015467	NDK domain-containing protein; Belongs to the NDK family.	Nucleoside diphosphate kinase.	0.919
LOC106918744	nme7	ENSPMEP00000034951	ENSPMEP00000032704	NDK domain-containing protein; Belongs to the NDK family.	Nucleoside diphosphate kinase 7; Belongs to the NDK family.	0.910
LOC106927218	LOC106918744	ENSPMEP00000030216	ENSPMEP00000034951	Nucleoside diphosphate kinase.	NDK domain-containing protein; Belongs to the NDK family.	0.901
LOC106927218	LOC106931198	ENSPMEP00000030216	ENSPMEP00000016366	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.958
LOC106927218	itpa	ENSPMEP00000030216	ENSPMEP00000001664	Nucleoside diphosphate kinase.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.971
LOC106927218	nme3	ENSPMEP00000030216	ENSPMEP00000014874	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.901
LOC106927218	nme6	ENSPMEP00000030216	ENSPMEP00000015467	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.916
LOC106927218	nme7	ENSPMEP00000030216	ENSPMEP00000032704	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase 7; Belongs to the NDK family.	0.908
LOC106931198	LOC106918744	ENSPMEP00000016366	ENSPMEP00000034951	Nucleoside diphosphate kinase.	NDK domain-containing protein; Belongs to the NDK family.	0.958
LOC106931198	LOC106927218	ENSPMEP00000016366	ENSPMEP00000030216	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.958
LOC106931198	itpa	ENSPMEP00000016366	ENSPMEP00000001664	Nucleoside diphosphate kinase.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.971
LOC106931198	nme3	ENSPMEP00000016366	ENSPMEP00000014874	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.958
LOC106931198	nme6	ENSPMEP00000016366	ENSPMEP00000015467	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase.	0.953
LOC106931198	nme7	ENSPMEP00000016366	ENSPMEP00000032704	Nucleoside diphosphate kinase.	Nucleoside diphosphate kinase 7; Belongs to the NDK family.	0.915
adss1	atic	ENSPMEP00000004242	ENSPMEP00000000353	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	0.995
adss1	gmps	ENSPMEP00000004242	ENSPMEP00000011260	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Guanine monophosphate synthase.	0.603

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