tlk2 protein (Poecilia mexicana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

tlk2

Tousled-like kinase 2. (737 aa)

Predicted Functional Partners:

asf1b

0.831

LOC106906233

0.831

LOC106927871

0.747

LOC106925294

0.747

LOC106929139

0.633

ARHGEF2

0.585

YTHDC2

0.574

smpd2

0.555

ENSPMEP00000010002

0.554

tbccd1

0.545

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF2	tlk2	ENSPMEP00000011838	ENSPMEP00000001680	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Tousled-like kinase 2.	0.585
ENSPMEP00000010002	tlk2	ENSPMEP00000010002	ENSPMEP00000001680	Myelin basic protein b.	Tousled-like kinase 2.	0.554
LOC106906233	LOC106925294	ENSPMEP00000019946	ENSPMEP00000016558	Anti-silencing function 1Ba histone chaperone.	TPR_REGION domain-containing protein.	0.953
LOC106906233	LOC106927871	ENSPMEP00000019946	ENSPMEP00000015970	Anti-silencing function 1Ba histone chaperone.	Calcineurin binding protein 1.	0.953
LOC106906233	LOC106929139	ENSPMEP00000019946	ENSPMEP00000018587	Anti-silencing function 1Ba histone chaperone.	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	0.982
LOC106906233	tlk2	ENSPMEP00000019946	ENSPMEP00000001680	Anti-silencing function 1Ba histone chaperone.	Tousled-like kinase 2.	0.831
LOC106925294	LOC106906233	ENSPMEP00000016558	ENSPMEP00000019946	TPR_REGION domain-containing protein.	Anti-silencing function 1Ba histone chaperone.	0.953
LOC106925294	LOC106929139	ENSPMEP00000016558	ENSPMEP00000018587	TPR_REGION domain-containing protein.	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	0.990
LOC106925294	asf1b	ENSPMEP00000016558	ENSPMEP00000004129	TPR_REGION domain-containing protein.	Anti-silencing function 1Ba histone chaperone.	0.953
LOC106925294	tlk2	ENSPMEP00000016558	ENSPMEP00000001680	TPR_REGION domain-containing protein.	Tousled-like kinase 2.	0.747
LOC106927871	LOC106906233	ENSPMEP00000015970	ENSPMEP00000019946	Calcineurin binding protein 1.	Anti-silencing function 1Ba histone chaperone.	0.953
LOC106927871	LOC106929139	ENSPMEP00000015970	ENSPMEP00000018587	Calcineurin binding protein 1.	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	0.990
LOC106927871	asf1b	ENSPMEP00000015970	ENSPMEP00000004129	Calcineurin binding protein 1.	Anti-silencing function 1Ba histone chaperone.	0.953
LOC106927871	tlk2	ENSPMEP00000015970	ENSPMEP00000001680	Calcineurin binding protein 1.	Tousled-like kinase 2.	0.747
LOC106929139	LOC106906233	ENSPMEP00000018587	ENSPMEP00000019946	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Anti-silencing function 1Ba histone chaperone.	0.982
LOC106929139	LOC106925294	ENSPMEP00000018587	ENSPMEP00000016558	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	TPR_REGION domain-containing protein.	0.990
LOC106929139	LOC106927871	ENSPMEP00000018587	ENSPMEP00000015970	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Calcineurin binding protein 1.	0.990
LOC106929139	asf1b	ENSPMEP00000018587	ENSPMEP00000004129	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Anti-silencing function 1Ba histone chaperone.	0.982
LOC106929139	tlk2	ENSPMEP00000018587	ENSPMEP00000001680	Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.	Tousled-like kinase 2.	0.633
YTHDC2	tlk2	ENSPMEP00000029450	ENSPMEP00000001680	YTH domain containing 2.	Tousled-like kinase 2.	0.574