usp7 protein (Poecilia mexicana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

usp7

Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1184 aa)

Predicted Functional Partners:

LOC106911031

0.997

tp53

0.995

mdm2

0.995

gmps

0.991

trip12

0.991

mdm4

0.989

chek1

0.984

dnmt1

0.982

ctnnb1

0.981

foxo4

0.981

Your Current Organism:

Poecilia mexicana

NCBI taxonomy Id: 48701
Other names: shortfin molly

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC106911031	dnmt1	ENSPMEP00000011454	ENSPMEP00000009549	Death-domain associated protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.966
LOC106911031	mdm2	ENSPMEP00000011454	ENSPMEP00000030417	Death-domain associated protein.	MDM2 proto-oncogene.	0.992
LOC106911031	mdm4	ENSPMEP00000011454	ENSPMEP00000016544	Death-domain associated protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.933
LOC106911031	tp53	ENSPMEP00000011454	ENSPMEP00000001243	Death-domain associated protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.988
LOC106911031	usp7	ENSPMEP00000011454	ENSPMEP00000001792	Death-domain associated protein.	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.997
chek1	dnmt1	ENSPMEP00000001319	ENSPMEP00000009549	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.801
chek1	mdm2	ENSPMEP00000001319	ENSPMEP00000030417	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	MDM2 proto-oncogene.	0.824
chek1	mdm4	ENSPMEP00000001319	ENSPMEP00000016544	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.846
chek1	tp53	ENSPMEP00000001319	ENSPMEP00000001243	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
chek1	usp7	ENSPMEP00000001319	ENSPMEP00000001792	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.984
ctnnb1	dnmt1	ENSPMEP00000002621	ENSPMEP00000009549	Catenin (cadherin-associated protein), beta 1.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.906
ctnnb1	foxo4	ENSPMEP00000002621	ENSPMEP00000007742	Catenin (cadherin-associated protein), beta 1.	Forkhead box O4.	0.629
ctnnb1	mdm2	ENSPMEP00000002621	ENSPMEP00000030417	Catenin (cadherin-associated protein), beta 1.	MDM2 proto-oncogene.	0.924
ctnnb1	mdm4	ENSPMEP00000002621	ENSPMEP00000016544	Catenin (cadherin-associated protein), beta 1.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.597
ctnnb1	tp53	ENSPMEP00000002621	ENSPMEP00000001243	Catenin (cadherin-associated protein), beta 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.788
ctnnb1	usp7	ENSPMEP00000002621	ENSPMEP00000001792	Catenin (cadherin-associated protein), beta 1.	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.981
dnmt1	LOC106911031	ENSPMEP00000009549	ENSPMEP00000011454	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Death-domain associated protein.	0.966
dnmt1	chek1	ENSPMEP00000009549	ENSPMEP00000001319	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.801
dnmt1	ctnnb1	ENSPMEP00000009549	ENSPMEP00000002621	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Catenin (cadherin-associated protein), beta 1.	0.906
dnmt1	mdm4	ENSPMEP00000009549	ENSPMEP00000016544	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.414