Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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[Homology]
Score
LOC106909894DBF4-type domain-containing protein. (698 aa)    
Predicted Functional Partners:
cdc7
Cell division cycle 7 homolog (S. cerevisiae).
   
 0.990
mcm4
DNA helicase; Belongs to the MCM family.
   
 0.975
mcm10
Minichromosome maintenance 10 replication initiation factor.
   
 0.966
orc2
Origin recognition complex, subunit 2.
   
 0.963
mcm2
DNA helicase; Belongs to the MCM family.
   
 0.961
atr
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 0.955
mcm3
DNA helicase; Belongs to the MCM family.
   
 0.952
mcm7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 0.946
chek2
Checkpoint kinase 2.
   
 
 0.945
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.933
Your Current Organism:
Poecilia mexicana
NCBI taxonomy Id: 48701
Other names: shortfin molly
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