STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
usp16Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (837 aa)    
Predicted Functional Partners:
LOC106923389
Ubiquitin-like domain-containing protein.
    
  0.819
rps27a
Ribosomal protein S27a.
    
  0.714
mysm1
Myb-like, SWIRM and MPN domains 1.
   
  
 0.617
ercc1
Excision repair cross-complementation group 1.
    
 0.617
ADCY9-2
Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
      
 0.568
ACKR3
Atypical chemokine receptor 3.
      
 0.568
ENSPMEP00000005358
Histone H2A; Belongs to the histone H2A family.
    
 0.553
ENSPMEP00000007359
Histone H2A; Belongs to the histone H2A family.
    
 0.553
LOC106914991
Ubiquitin like 4A.
    
 0.553
ENSPMEP00000007889
Histone H2A; Belongs to the histone H2A family.
    
 0.553
Your Current Organism:
Poecilia mexicana
NCBI taxonomy Id: 48701
Other names: shortfin molly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.