node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDR71930.1 | SDS38884.1 | SAMN05216421_0118 | SAMN05216421_1435 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.782 |
SDR71930.1 | SDS83574.1 | SAMN05216421_0118 | SAMN05216421_2291 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Homoserine dehydrogenase. | 0.815 |
SDR71930.1 | glyA | SAMN05216421_0118 | SAMN05216421_0315 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.779 |
SDR71930.1 | hisA | SAMN05216421_0118 | SAMN05216421_3197 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.826 |
SDR71930.1 | hisB | SAMN05216421_0118 | SAMN05216421_3199 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazoleglycerol-phosphate dehydratase. | 0.843 |
SDR71930.1 | hisF | SAMN05216421_0118 | SAMN05216421_3196 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.874 |
SDR71930.1 | hisH | SAMN05216421_0118 | SAMN05216421_3198 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.858 |
SDR71930.1 | hisI | SAMN05216421_0118 | SAMN05216421_2716 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.850 |
SDR71930.1 | hisZ | SAMN05216421_0118 | SAMN05216421_0387 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.863 |
SDR71930.1 | serC | SAMN05216421_0118 | SAMN05216421_1848 | HAD-superfamily subfamily IB hydrolase, TIGR01490. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.835 |
SDS38884.1 | SDR71930.1 | SAMN05216421_1435 | SAMN05216421_0118 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.782 |
SDS38884.1 | SDS83574.1 | SAMN05216421_1435 | SAMN05216421_2291 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.960 |
SDS38884.1 | glyA | SAMN05216421_1435 | SAMN05216421_0315 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.819 |
SDS38884.1 | hisI | SAMN05216421_1435 | SAMN05216421_2716 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.449 |
SDS83574.1 | SDR71930.1 | SAMN05216421_2291 | SAMN05216421_0118 | Homoserine dehydrogenase. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.815 |
SDS83574.1 | SDS38884.1 | SAMN05216421_2291 | SAMN05216421_1435 | Homoserine dehydrogenase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.960 |
SDS83574.1 | glyA | SAMN05216421_2291 | SAMN05216421_0315 | Homoserine dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.806 |
SDS83574.1 | hisA | SAMN05216421_2291 | SAMN05216421_3197 | Homoserine dehydrogenase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.610 |
SDS83574.1 | hisB | SAMN05216421_2291 | SAMN05216421_3199 | Homoserine dehydrogenase. | Imidazoleglycerol-phosphate dehydratase. | 0.466 |
SDS83574.1 | hisF | SAMN05216421_2291 | SAMN05216421_3196 | Homoserine dehydrogenase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.606 |