STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbiX-2Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (131 aa)    
Predicted Functional Partners:
SFM14431.1
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase.
  
 
 0.884
SFM17088.1
uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 
 0.789
SFM46802.1
precorrin-6Y C5,15-methyltransferase (decarboxylating).
 
  
 0.693
SFM45176.1
Cobalt-factor II C20-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.690
SFM45084.1
Precorrin-3 methyltransferase.
 
  
 0.665
SFM17104.1
uroporphyrinogen-III synthase.
  
 
 0.636
cbiT
cobalt-precorrin-6B (C15)-methyltransferase; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
    
 0.624
SFM19281.1
Phosphoadenylylsulfate reductase (thioredoxin).
 
  
 0.608
cbiA
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydro [...]
    
 0.590
SFM45124.1
Cobalt-precorrin 5A hydrolase; Non-canonical start codon; manually curated.
 
  
 0.583
Your Current Organism:
Methanolobus profundi
NCBI taxonomy Id: 487685
Other names: DSM 21213, M. profundi, Methanolobus profundi Mochimaru et al. 2009, Methanolobus sp. MobM, NBRC 104158, strain Mob M, strain MobM
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