STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFM22546.1CO dehydrogenase maturation factor. (250 aa)    
Predicted Functional Partners:
cdhC
acetyl-CoA decarbonylase/synthase beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex).
 
  
 0.988
cdhD
acetyl-CoA decarbonylase/synthase delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.
 
  
 0.986
cdhE
acetyl-CoA decarbonylase/synthase gamma subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
 
  
 0.984
cdhB
acetyl-CoA decarbonylase/synthase epsilon subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation.
 
    0.947
cdhA
acetyl-CoA decarbonylase/synthase alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
 
  
 0.929
SFM55742.1
Formylmethanofuran dehydrogenase, subunit G.
 
  
 0.899
SFM50202.1
Methylene-tetrahydrofolate reductase C terminal.
  
     0.674
SFM28435.1
CO dehydrogenase/acetyl-CoA synthase delta subunit.
 
  
 0.620
SFM50714.1
5,10-methylenetetrahydrofolate reductase.
 
   
 0.524
SFM79593.1
Hypothetical protein.
 
     0.467
Your Current Organism:
Methanolobus profundi
NCBI taxonomy Id: 487685
Other names: DSM 21213, M. profundi, Methanolobus profundi Mochimaru et al. 2009, Methanolobus sp. MobM, NBRC 104158, strain Mob M, strain MobM
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.