node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFM30890.1 | SFM57135.1 | SAMN04488696_0875 | SAMN04488696_1652 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.791 |
SFM30890.1 | SFM57155.1 | SAMN04488696_0875 | SAMN04488696_1653 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.995 |
SFM30890.1 | SFM70498.1 | SAMN04488696_0875 | SAMN04488696_2130 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.717 |
SFM30890.1 | SFM88808.1 | SAMN04488696_0875 | SAMN04488696_2732 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase. | 0.744 |
SFM30890.1 | cimA | SAMN04488696_0875 | SAMN04488696_1651 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.903 |
SFM30890.1 | hacB | SAMN04488696_0875 | SAMN04488696_2734 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.672 |
SFM30890.1 | ilvC | SAMN04488696_0875 | SAMN04488696_1654 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.986 |
SFM30890.1 | ilvD | SAMN04488696_0875 | SAMN04488696_0307 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.926 |
SFM30890.1 | leuC | SAMN04488696_0875 | SAMN04488696_0297 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.655 |
SFM30890.1 | leuD | SAMN04488696_0875 | SAMN04488696_1411 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.664 |
SFM57135.1 | SFM30890.1 | SAMN04488696_1652 | SAMN04488696_0875 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.791 |
SFM57135.1 | SFM57155.1 | SAMN04488696_1652 | SAMN04488696_1653 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SFM57135.1 | SFM70498.1 | SAMN04488696_1652 | SAMN04488696_2130 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.796 |
SFM57135.1 | SFM88808.1 | SAMN04488696_1652 | SAMN04488696_2732 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase. | 0.744 |
SFM57135.1 | cimA | SAMN04488696_1652 | SAMN04488696_1651 | Acetolactate synthase, large subunit. | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.960 |
SFM57135.1 | hacB | SAMN04488696_1652 | SAMN04488696_2734 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.672 |
SFM57135.1 | ilvC | SAMN04488696_1652 | SAMN04488696_1654 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
SFM57135.1 | ilvD | SAMN04488696_1652 | SAMN04488696_0307 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.958 |
SFM57135.1 | leuC | SAMN04488696_1652 | SAMN04488696_0297 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.655 |
SFM57135.1 | leuD | SAMN04488696_1652 | SAMN04488696_1411 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.664 |