STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFM76768.1Fanconi anemia group M protein. (756 aa)    
Predicted Functional Partners:
SFM77674.1
ATP-dependent DNA helicase RecQ.
   
 0.981
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.952
rpl1
LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.938
SFM73081.1
Replication factor A1.
 
 
 0.893
SFM85724.1
Replication factor A1.
 
 
 0.863
rpl40e
LSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 
  0.852
SFM85854.1
Replication factor A1.
   
 0.828
SFM42960.1
Malate dehydrogenase (NAD); Belongs to the LDH/MDH superfamily.
    
 0.823
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 
 
 0.789
SFM66098.1
Replicative DNA polymerase I.
 
 
 0.782
Your Current Organism:
Methanolobus profundi
NCBI taxonomy Id: 487685
Other names: DSM 21213, M. profundi, Methanolobus profundi Mochimaru et al. 2009, Methanolobus sp. MobM, NBRC 104158, strain Mob M, strain MobM
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.