node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFL85043.1 | trpA | SAMN04487963_0217 | SAMN04487963_2939 | Anthranilate synthase, component II. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.989 |
SFL85043.1 | trpB-2 | SAMN04487963_0217 | SAMN04487963_2938 | Anthranilate synthase, component II. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.967 |
SFL85043.1 | trpC | SAMN04487963_0217 | SAMN04487963_0219 | Anthranilate synthase, component II. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.999 |
SFL85043.1 | trpD | SAMN04487963_0217 | SAMN04487963_0218 | Anthranilate synthase, component II. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
SFL85043.1 | trpF | SAMN04487963_0217 | SAMN04487963_2937 | Anthranilate synthase, component II. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.999 |
SFL98237.1 | SFM39380.1 | SAMN04487963_0851 | SAMN04487963_2389 | Glyoxylate/hydroxypyruvate reductase A. | Phosphoserine phosphatase. | 0.533 |
SFL98237.1 | ilvA | SAMN04487963_0851 | SAMN04487963_3252 | Glyoxylate/hydroxypyruvate reductase A. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.973 |
SFL98237.1 | trpA | SAMN04487963_0851 | SAMN04487963_2939 | Glyoxylate/hydroxypyruvate reductase A. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.964 |
SFL98237.1 | trpB-2 | SAMN04487963_0851 | SAMN04487963_2938 | Glyoxylate/hydroxypyruvate reductase A. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.972 |
SFM16117.1 | ilvA | SAMN04487963_1468 | SAMN04487963_3252 | Lactoylglutathione lyase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.944 |
SFM16117.1 | trpB-2 | SAMN04487963_1468 | SAMN04487963_2938 | Lactoylglutathione lyase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.968 |
SFM39380.1 | SFL98237.1 | SAMN04487963_2389 | SAMN04487963_0851 | Phosphoserine phosphatase. | Glyoxylate/hydroxypyruvate reductase A. | 0.533 |
SFM39380.1 | glyA-2 | SAMN04487963_2389 | SAMN04487963_3094 | Phosphoserine phosphatase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.990 |
SFM39380.1 | ilvA | SAMN04487963_2389 | SAMN04487963_3252 | Phosphoserine phosphatase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.970 |
SFM39380.1 | trpA | SAMN04487963_2389 | SAMN04487963_2939 | Phosphoserine phosphatase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.965 |
SFM39380.1 | trpB-2 | SAMN04487963_2389 | SAMN04487963_2938 | Phosphoserine phosphatase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.969 |
SFM39380.1 | trpC | SAMN04487963_2389 | SAMN04487963_0219 | Phosphoserine phosphatase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.554 |
SFM39380.1 | trpF | SAMN04487963_2389 | SAMN04487963_2937 | Phosphoserine phosphatase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.618 |
glyA-2 | SFM39380.1 | SAMN04487963_3094 | SAMN04487963_2389 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase. | 0.990 |
glyA-2 | ilvA | SAMN04487963_3094 | SAMN04487963_3252 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.969 |