Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KHS46612.1Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)    
Predicted Functional Partners:
KHS46935.1
Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.994
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.983
sucA
2-oxoglutarate dehydrogenase E1.
   
 0.981
KHS48985.1
Citrate synthase; Belongs to the citrate synthase family.
  
 0.969
KHS47745.1
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.963
KHS46809.1
Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein.
   
 
 0.955
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.947
KHS43441.1
Glutamate synthase (NADH) large subunit.
    
 0.939
KHS46810.1
2-oxoglutarate ferredoxin oxidoreductase subunit beta.
     
 0.885
nuoI
NADH dehydrogenase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
   
 
 0.880
Your Current Organism:
Novosphingobium subterraneum
NCBI taxonomy Id: 48936
Other names: ATCC 700279, CIP 105153, DSM 12447, IFO 16086, N. subterraneum, NBRC 16086, Novosphingobium subterraneae, SMCC B0478, Sphingomonas subterrae, Sphingomonas subterranea, Sphingomonas subterraneae, strain B0478
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