STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yam8Calcium influx-promoting protein ehs1; Required for Ca(2+) influx and for vitality of cells in a late, pheromone-induced event of the mating process requiring calcium- induced signaling; To yeast MID1. (486 aa)    
Predicted Functional Partners:
cch1
Calcium-channel protein cch1; Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca(2+) are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments (By similarity).
  
 
 0.973
mnr2
Putative metal ion transporter C17A12.14; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
 
 
 
 0.887
SPBC27B12.12c
Putative metal ion transporter C27B12.12c.
 
  
 
 0.852
prz1
Transcriptional regulator prz1; Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates pmc1.
    
 
 0.838
pmp1
Tyrosine-protein phosphatase pmp1; Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
   
 
 0.829
trp1322
Uncharacterized membrane protein C1322.03.
   
 
 0.821
pmk1
Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions.
 
  
 
 0.809
trp663
Uncharacterized membrane protein C663.14c.
    
 
 0.768
pek1
MAP kinase kinase skh1/pek1; Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation.
   
 
 0.764
wis1
Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1.
   
 
 0.754
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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