node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arg1 | cys2 | O74548 | Q10341 | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Serine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity. | 0.624 |
arg1 | lys12 | O74548 | O14104 | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.489 |
arg1 | lys3 | O74548 | Q09694 | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family. | 0.880 |
arg1 | spe1 | O74548 | Q9UQW9 | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. | 0.493 |
arg1 | trp2 | O74548 | O13831 | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Tryptophan synthase; In the C-terminal section; belongs to the TrpB family. | 0.605 |
arg1 | ura1 | O74548 | Q09794 | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase). In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. | 0.760 |
cys2 | arg1 | Q10341 | O74548 | Serine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity. | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.624 |
cys2 | lys3 | Q10341 | Q09694 | Serine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity. | Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family. | 0.699 |
cys2 | trp2 | Q10341 | O13831 | Serine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity. | Tryptophan synthase; In the C-terminal section; belongs to the TrpB family. | 0.560 |
lys1 | lys12 | P40976 | O14104 | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.586 |
lys1 | lys2 | P40976 | Q9UT74 | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. | 0.758 |
lys1 | lys3 | P40976 | Q09694 | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family. | 0.796 |
lys1 | lys7 | P40976 | Q10474 | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha- aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity. | 0.879 |
lys1 | lys9 | P40976 | O59711 | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]; Belongs to the saccharopine dehydrogenase family. | 0.979 |
lys1 | trp2 | P40976 | O13831 | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | Tryptophan synthase; In the C-terminal section; belongs to the TrpB family. | 0.759 |
lys12 | arg1 | O14104 | O74548 | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.489 |
lys12 | lys1 | O14104 | P40976 | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. | 0.586 |
lys12 | lys2 | O14104 | Q9UT74 | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. | 0.991 |
lys12 | lys3 | O14104 | Q09694 | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family. | 0.708 |
lys12 | lys7 | O14104 | Q10474 | Homoisocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha- aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity. | 0.608 |