node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHG63830.1 | SHG96157.1 | SAMN04488068_0873 | SAMN04488068_1996 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.593 |
SHG63830.1 | SHH35936.1 | SAMN04488068_0873 | SAMN04488068_0054 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | 0.881 |
SHG63830.1 | metG | SAMN04488068_0873 | SAMN04488068_0214 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.681 |
SHG63830.1 | mnmE | SAMN04488068_0873 | SAMN04488068_0871 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.724 |
SHG63830.1 | rho | SAMN04488068_0873 | SAMN04488068_1846 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.684 |
SHG63830.1 | rnpA | SAMN04488068_0873 | SAMN04488068_0874 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.988 |
SHG63830.1 | rpmH | SAMN04488068_0873 | SAMN04488068_0875 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Large subunit ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. | 0.822 |
SHG63830.1 | rsmJ | SAMN04488068_0873 | SAMN04488068_3138 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 16S rRNA (guanine1516-N2)-methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. | 0.566 |
SHG63830.1 | serS | SAMN04488068_0873 | SAMN04488068_0517 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.783 |
SHG63830.1 | yidC | SAMN04488068_0873 | SAMN04488068_0872 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | YidC/Oxa1 family membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.945 |
SHG96157.1 | SHG63830.1 | SAMN04488068_1996 | SAMN04488068_0873 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.593 |
SHH35936.1 | SHG63830.1 | SAMN04488068_0054 | SAMN04488068_0873 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.881 |
SHH35936.1 | rho | SAMN04488068_0054 | SAMN04488068_1846 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.463 |
SHH35936.1 | rnpA | SAMN04488068_0054 | SAMN04488068_0874 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.503 |
SHH35936.1 | rpmH | SAMN04488068_0054 | SAMN04488068_0875 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Large subunit ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. | 0.841 |
SHH35936.1 | yidC | SAMN04488068_0054 | SAMN04488068_0872 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | YidC/Oxa1 family membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.936 |
metG | SHG63830.1 | SAMN04488068_0214 | SAMN04488068_0873 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.681 |
metG | mnmE | SAMN04488068_0214 | SAMN04488068_0871 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | tRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.420 |
metG | serS | SAMN04488068_0214 | SAMN04488068_0517 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.621 |
metG | yidC | SAMN04488068_0214 | SAMN04488068_0872 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | YidC/Oxa1 family membrane protein insertase; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.607 |