STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCY42760.1Dihydrofolate reductase. (192 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.812
SCY42785.1
Por secretion system C-terminal sorting domain-containing protein.
       0.773
SCY67194.1
Glyoxalase superfamily enzyme, possibly 3-demethylubiquinone-9 3-methyltransferase.
 
    0.551
SCY42814.1
Major Facilitator Superfamily protein.
       0.545
SCY67675.1
Cyanophycin synthetase; Belongs to the MurCDEF family.
  
 
 0.521
SCY72374.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase.
  
  
 0.470
tdk
Thymidine kinase.
  
 
 0.442
SCY64042.1
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.442
lipA
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
     
 0.417
SCY77227.1
dCMP deaminase.
  
 
 0.417
Your Current Organism:
Flavobacterium caeni
NCBI taxonomy Id: 490189
Other names: CGMCC 1.7031, F. caeni, Flavobacteriaceae bacterium LM5, Flavobacterium caeni Liu et al. 2010 emend. Fujii et al. 2014, NBRC 104239, strain LM5
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