| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DKAM_0002 | DKAM_0148 | DKAM_0002 | DKAM_0148 | Putative dehydrogenase (flavoprotein), FixC. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.557 |
| DKAM_0002 | DKAM_0159 | DKAM_0002 | DKAM_0159 | Putative dehydrogenase (flavoprotein), FixC. | Geranylgeranyl reductase. | 0.463 |
| DKAM_0002 | DKAM_0955 | DKAM_0002 | DKAM_0955 | Putative dehydrogenase (flavoprotein), FixC. | COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases. | 0.539 |
| DKAM_0002 | DKAM_1012 | DKAM_0002 | DKAM_1012 | Putative dehydrogenase (flavoprotein), FixC. | UbiA prenyltransferase. | 0.578 |
| DKAM_0002 | DKAM_1191 | DKAM_0002 | DKAM_1191 | Putative dehydrogenase (flavoprotein), FixC. | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.498 |
| DKAM_0002 | DKAM_1399 | DKAM_0002 | DKAM_1399 | Putative dehydrogenase (flavoprotein), FixC. | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.429 |
| DKAM_0002 | DKAM_1455 | DKAM_0002 | DKAM_1455 | Putative dehydrogenase (flavoprotein), FixC. | Polyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.459 |
| DKAM_0002 | dnaG | DKAM_0002 | DKAM_1292 | Putative dehydrogenase (flavoprotein), FixC. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.426 |
| DKAM_0002 | mvk | DKAM_0002 | DKAM_0131 | Putative dehydrogenase (flavoprotein), FixC. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.425 |
| DKAM_0002 | speH | DKAM_0002 | DKAM_0003 | Putative dehydrogenase (flavoprotein), FixC. | S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | 0.869 |
| DKAM_0148 | DKAM_0002 | DKAM_0148 | DKAM_0002 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | Putative dehydrogenase (flavoprotein), FixC. | 0.557 |
| DKAM_0148 | DKAM_0159 | DKAM_0148 | DKAM_0159 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | Geranylgeranyl reductase. | 0.949 |
| DKAM_0148 | DKAM_1012 | DKAM_0148 | DKAM_1012 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | UbiA prenyltransferase. | 0.976 |
| DKAM_0148 | DKAM_1191 | DKAM_0148 | DKAM_1191 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. | 0.737 |
| DKAM_0148 | dnaG | DKAM_0148 | DKAM_1292 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.579 |
| DKAM_0148 | mvk | DKAM_0148 | DKAM_0131 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.698 |
| DKAM_0159 | DKAM_0002 | DKAM_0159 | DKAM_0002 | Geranylgeranyl reductase. | Putative dehydrogenase (flavoprotein), FixC. | 0.463 |
| DKAM_0159 | DKAM_0148 | DKAM_0159 | DKAM_0148 | Geranylgeranyl reductase. | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | 0.949 |
| DKAM_0159 | DKAM_0955 | DKAM_0159 | DKAM_0955 | Geranylgeranyl reductase. | COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases. | 0.592 |
| DKAM_0159 | DKAM_1012 | DKAM_0159 | DKAM_1012 | Geranylgeranyl reductase. | UbiA prenyltransferase. | 0.970 |