C5L36_0C00420 protein (Pichia kudriavzevii) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

C5L36_0C00420

Uncharacterized protein. (413 aa)

Predicted Functional Partners:

C5L36_0A01420

0.866

C5L36_0C07510

0.845

C5L36_0A10120

0.844

C5L36_0B04090

0.752

C5L36_0D00285

0.510

C5L36_0B01060

0.453

C5L36_0B11690

0.431

BOH78_0123

0.420

C5L36_0E01205

0.419

C5L36_0D01490

0.415

Your Current Organism:

Pichia kudriavzevii

NCBI taxonomy Id: 4909
Other names: AJ 4457 [[Candida krusei]], ATCC 24210, ATCC 6258 [[Candida krusei]], ATCC 749 [[Candida krusei]], CBS 5147, CBS 5147 T, CBS 573 [[Candida krusei]], Candida acidothermophilum, Candida krusei, DBVPG 7230 [[Candida krusei]], IAM 12186 [[Candida krusei]], Issatchenkia orientalis, NRRL Y-413 [[Candida krusei]], NRRL Y-5396, NRRL Y-7179 [[Candida krusei]], P. kudriavzevii, Saccharomyces krusei, Saccharomyces sp. p1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOH78_0123	C5L36_0C00420	A0A1V2LV71	A0A2U9R4V6	Protein CCC1.	Uncharacterized protein.	0.420
C5L36_0A01420	C5L36_0A10120	A0A1Z8JRH3	A0A2U9QZI2	FET3; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.826
C5L36_0A01420	C5L36_0C00420	A0A1Z8JRH3	A0A2U9R4V6	FET3; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.866
C5L36_0A01420	C5L36_0C07510	A0A1Z8JRH3	A0A2U9R648	FET3; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.829
C5L36_0A10120	C5L36_0A01420	A0A2U9QZI2	A0A1Z8JRH3	Uncharacterized protein.	FET3; Belongs to the multicopper oxidase family.	0.826
C5L36_0A10120	C5L36_0B01060	A0A2U9QZI2	A0A2U9R146	Uncharacterized protein.	Response regulatory domain-containing protein.	0.453
C5L36_0A10120	C5L36_0B04090	A0A2U9QZI2	A0A2U9R1H5	Uncharacterized protein.	Uncharacterized protein; Belongs to the multicopper oxidase family.	0.675
C5L36_0A10120	C5L36_0B11690	A0A2U9QZI2	A0A2U9R3M3	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.431
C5L36_0A10120	C5L36_0C00420	A0A2U9QZI2	A0A2U9R4V6	Uncharacterized protein.	Uncharacterized protein.	0.844
C5L36_0A10120	C5L36_0D00285	A0A2U9QZI2	A0A2U9R8N4	Uncharacterized protein.	Plastocyanin-like domain-containing protein.	0.510
C5L36_0A10120	C5L36_0D01490	A0A2U9QZI2	A0A099NZQ2	Uncharacterized protein.	Uncharacterized protein.	0.415
C5L36_0A10120	C5L36_0E01205	A0A2U9QZI2	A0A2U9RB06	Uncharacterized protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.419
C5L36_0B01060	C5L36_0A10120	A0A2U9R146	A0A2U9QZI2	Response regulatory domain-containing protein.	Uncharacterized protein.	0.453
C5L36_0B01060	C5L36_0C00420	A0A2U9R146	A0A2U9R4V6	Response regulatory domain-containing protein.	Uncharacterized protein.	0.453
C5L36_0B01060	C5L36_0C07510	A0A2U9R146	A0A2U9R648	Response regulatory domain-containing protein.	Uncharacterized protein.	0.453
C5L36_0B04090	C5L36_0A10120	A0A2U9R1H5	A0A2U9QZI2	Uncharacterized protein; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.675
C5L36_0B04090	C5L36_0C00420	A0A2U9R1H5	A0A2U9R4V6	Uncharacterized protein; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.752
C5L36_0B04090	C5L36_0C07510	A0A2U9R1H5	A0A2U9R648	Uncharacterized protein; Belongs to the multicopper oxidase family.	Uncharacterized protein.	0.678
C5L36_0B11690	C5L36_0A10120	A0A2U9R3M3	A0A2U9QZI2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.431
C5L36_0B11690	C5L36_0C00420	A0A2U9R3M3	A0A2U9R4V6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.431

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.776

expected number of edges:

20

PPI enrichment p-value:

0.0147

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

5 of 89

1.75

1.88

6.53e-05

GO:0045471

Response to ethanol

2 of 3

2.83

1.2

0.0066

GO:0006636

Unsaturated fatty acid biosynthetic process

2 of 5

2.6

1.06

0.0116

GO:0042128

Nitrate assimilation

2 of 7

2.46

1.03

0.0133

GO:0000001

Mitochondrion inheritance

2 of 11

2.26

0.88

0.0235

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.0

1.42

0.0027

GO:0004768

stearoyl-CoA 9-desaturase activity

2 of 2

3.0

1.42

0.0027

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.6

1.37

0.0031

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 22

2.14

1.35

0.0027

GO:0030151

Molybdenum ion binding

2 of 8

2.4

1.21

0.0060

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

5 of 12

2.62

4.58

1.74e-09

GO:0005736

RNA polymerase I complex

2 of 12

2.22

1.16

0.0069

GO:0005666

RNA polymerase III complex

2 of 17

2.07

1.04

0.0107

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3528

RNA polymerase II, core complex

3 of 7

2.63

2.03

0.00018

CL:3508

Mixed, incl. DNA-directed RNA polymerase complex, and Transcription elongation factor complex

5 of 130

1.59

0.00018

CL:14325

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Nitrate assimilation

2 of 5

2.6

1.34

0.0035

CL:13072

Fatty acid metabolism

2 of 6

2.53

1.3

0.0042

CL:3733

RNA polymerase I complex

2 of 10

2.3

1.1

0.0092

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

5 of 41

2.09

3.35

7.00e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

5 of 27

2.27

3.57

6.18e-08

MAP-72086

mRNA Capping

5 of 29

2.24

3.54

6.18e-08

MAP-113418

Formation of the Early Elongation Complex

5 of 29

2.24

3.54

6.18e-08

MAP-75955

RNA Polymerase II Transcription Elongation

5 of 38

2.12

3.38

7.35e-08

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

5 of 38

2.12

3.38

7.35e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

5 of 76

1.82

2.27

8.31e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 19

2.2

1.85

0.00028

KW-0275

Fatty acid biosynthesis

2 of 8

2.4

1.25

0.0050

KW-0249

Electron transport

2 of 17

2.07

1.12

0.0076

KW-0349

Heme

3 of 100

1.48

0.96

0.0076

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00174

Oxidoreductase molybdopterin binding domain

2 of 3

2.83

1.12

0.0096

PF00487

Fatty acid desaturase

2 of 10

2.3

0.82

0.0317

PF00970

Oxidoreductase FAD-binding domain

2 of 12

2.22

0.81

0.0317

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001199

Cytochrome b5-like heme/steroid binding domain

4 of 29

2.14

2.13

6.50e-05

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

4 of 30

2.13

2.12

6.50e-05

IPR018506

Cytochrome b5, heme-binding site

3 of 15

2.3

1.71

0.00060

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 3

2.83

1.32

0.0041

IPR015876

Acyl-CoA desaturase

2 of 2

3.0

1.32

0.0041

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

4 of 29

2.14

2.56

7.23e-06

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