node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEF53576.1 | AEF55353.1 | Mar181_0516 | Mar181_2317 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | 0.824 |
AEF53576.1 | hisB | Mar181_0516 | Mar181_0424 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: pag:PLES_55341 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.863 |
AEF53576.1 | hisD | Mar181_0516 | Mar181_1967 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.861 |
AEF53576.1 | hisE | Mar181_0516 | Mar181_0453 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphatase; KEGG: maq:Maqu_3419 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase. | 0.843 |
AEF53576.1 | hisF | Mar181_0516 | Mar181_0422 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.854 |
AEF53576.1 | hisG | Mar181_0516 | Mar181_1968 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.824 |
AEF53576.1 | hisH | Mar181_0516 | Mar181_0423 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.850 |
AEF53576.1 | hisI | Mar181_0516 | Mar181_1574 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.869 |
AEF53576.1 | hisZ | Mar181_0516 | Mar181_1443 | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.738 |
AEF55353.1 | AEF53576.1 | Mar181_2317 | Mar181_0516 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | 0.824 |
AEF55353.1 | hisB | Mar181_2317 | Mar181_0424 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: pag:PLES_55341 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.935 |
AEF55353.1 | hisC | Mar181_2317 | Mar181_2714 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: ppw:PputW619_4248 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.912 |
AEF55353.1 | hisD | Mar181_2317 | Mar181_1967 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.935 |
AEF55353.1 | hisE | Mar181_2317 | Mar181_0453 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphatase; KEGG: maq:Maqu_3419 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase. | 0.935 |
AEF55353.1 | hisF | Mar181_2317 | Mar181_0422 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.993 |
AEF55353.1 | hisG | Mar181_2317 | Mar181_1968 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.935 |
AEF55353.1 | hisH | Mar181_2317 | Mar181_0423 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.994 |
AEF55353.1 | hisI | Mar181_2317 | Mar181_1574 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.993 |
AEF55353.1 | hisZ | Mar181_2317 | Mar181_1443 | KEGG: pcs:Pc12g06840 Pc12g06840; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic; PFAM: Histidine biosynthesis; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.909 |
hisB | AEF53576.1 | Mar181_0424 | Mar181_0516 | HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: pag:PLES_55341 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | PFAM: Aminotransferase, class I/II; KEGG: gpb:HDN1F_08150 cobalamin biosynthesis protein, aminopropanol attachment. | 0.863 |