node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AEF53663.1 | AEF53664.1 | Mar181_0606 | Mar181_0607 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | 0.998 |
AEF53663.1 | AEF55616.1 | Mar181_0606 | Mar181_2585 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | KEGG: maq:Maqu_0883 acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. | 0.773 |
AEF53663.1 | AEF55617.1 | Mar181_0606 | Mar181_2586 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: maq:Maqu_0882 acetolactate synthase 3 catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. | 0.994 |
AEF53663.1 | AEF56246.1 | Mar181_0606 | Mar181_3223 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | KEGG: maq:Maqu_0824 malate dehydrogenase; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal. | 0.515 |
AEF53663.1 | ilvC | Mar181_0606 | Mar181_2965 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.973 |
AEF53663.1 | leuA | Mar181_0606 | Mar181_1582 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.856 |
AEF53663.1 | leuB | Mar181_0606 | Mar181_1891 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.973 |
AEF53663.1 | leuC | Mar181_0606 | Mar181_1893 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.962 |
AEF53663.1 | leuD | Mar181_0606 | Mar181_1892 | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.965 |
AEF53664.1 | AEF53663.1 | Mar181_0607 | Mar181_0606 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | KEGG: pau:PA14_16070 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT. | 0.998 |
AEF53664.1 | AEF53736.1 | Mar181_0607 | Mar181_0680 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | TIGRFAM: Oxaloacetate decarboxylase, alpha subunit; KEGG: maq:Maqu_0971 oxaloacetate decarboxylase; PFAM: Conserved carboxylase region; Pyruvate carboxyltransferase; Biotin/lipoyl attachment. | 0.437 |
AEF53664.1 | AEF55616.1 | Mar181_0607 | Mar181_2585 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | KEGG: maq:Maqu_0883 acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. | 0.546 |
AEF53664.1 | AEF55617.1 | Mar181_0607 | Mar181_2586 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: maq:Maqu_0882 acetolactate synthase 3 catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. | 0.517 |
AEF53664.1 | ilvC | Mar181_0607 | Mar181_2965 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.734 |
AEF53664.1 | leuB | Mar181_0607 | Mar181_1891 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.560 |
AEF53664.1 | leuC | Mar181_0607 | Mar181_1893 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.597 |
AEF53664.1 | leuD | Mar181_0607 | Mar181_1892 | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.878 |
AEF53736.1 | AEF53664.1 | Mar181_0680 | Mar181_0607 | TIGRFAM: Oxaloacetate decarboxylase, alpha subunit; KEGG: maq:Maqu_0971 oxaloacetate decarboxylase; PFAM: Conserved carboxylase region; Pyruvate carboxyltransferase; Biotin/lipoyl attachment. | TIGRFAM: Threonine synthase; KEGG: maq:Maqu_2273 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. | 0.437 |
AEF53736.1 | AEF55616.1 | Mar181_0680 | Mar181_2585 | TIGRFAM: Oxaloacetate decarboxylase, alpha subunit; KEGG: maq:Maqu_0971 oxaloacetate decarboxylase; PFAM: Conserved carboxylase region; Pyruvate carboxyltransferase; Biotin/lipoyl attachment. | KEGG: maq:Maqu_0883 acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. | 0.801 |
AEF53736.1 | AEF55617.1 | Mar181_0680 | Mar181_2586 | TIGRFAM: Oxaloacetate decarboxylase, alpha subunit; KEGG: maq:Maqu_0971 oxaloacetate decarboxylase; PFAM: Conserved carboxylase region; Pyruvate carboxyltransferase; Biotin/lipoyl attachment. | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: maq:Maqu_0882 acetolactate synthase 3 catalytic subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. | 0.818 |