node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDK09800.1 | SDK57108.1 | SAMN05192566_0078 | SAMN05192566_1705 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.776 |
SDK09800.1 | SDK57132.1 | SAMN05192566_0078 | SAMN05192566_1706 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit. | 0.626 |
SDK09800.1 | edd | SAMN05192566_0078 | SAMN05192566_1209 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.627 |
SDK09800.1 | ilvC | SAMN05192566_0078 | SAMN05192566_1704 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.770 |
SDK09800.1 | ilvD | SAMN05192566_0078 | SAMN05192566_2617 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.767 |
SDK09800.1 | leuA-2 | SAMN05192566_0078 | SAMN05192566_2510 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.500 |
SDK09800.1 | leuB | SAMN05192566_0078 | SAMN05192566_0074 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.891 |
SDK09800.1 | leuC | SAMN05192566_0078 | SAMN05192566_0076 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.870 |
SDK09800.1 | leuD | SAMN05192566_0078 | SAMN05192566_0075 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.871 |
SDK57108.1 | SDK09800.1 | SAMN05192566_1705 | SAMN05192566_0078 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.776 |
SDK57108.1 | SDK57132.1 | SAMN05192566_1705 | SAMN05192566_1706 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SDK57108.1 | edd | SAMN05192566_1705 | SAMN05192566_1209 | Acetolactate synthase, small subunit. | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.710 |
SDK57108.1 | ilvC | SAMN05192566_1705 | SAMN05192566_1704 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SDK57108.1 | ilvD | SAMN05192566_1705 | SAMN05192566_2617 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.849 |
SDK57108.1 | leuA | SAMN05192566_1705 | SAMN05192566_1069 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.832 |
SDK57108.1 | leuA-2 | SAMN05192566_1705 | SAMN05192566_2510 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.866 |
SDK57108.1 | leuB | SAMN05192566_1705 | SAMN05192566_0074 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.971 |
SDK57108.1 | leuC | SAMN05192566_1705 | SAMN05192566_0076 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.907 |
SDK57108.1 | leuD | SAMN05192566_1705 | SAMN05192566_0075 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.929 |
SDK57132.1 | SDK09800.1 | SAMN05192566_1706 | SAMN05192566_0078 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.626 |