STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macBMacrolide ABC transporter permease/ATP-binding protein MacB; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (646 aa)    
Predicted Functional Partners:
macA
Efflux transporter periplasmic adaptor subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.999
acrA
Efflux transporter periplasmic adaptor subunit; MexX; AmrA; involved in resistance to antibiotics; periplasmic membrane fusion protein; functions along with MexY and OprM; part of an inducible system that appears to respond to interference with the cellular translation machinery; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
lolE
Permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.994
mtrE_3
Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.978
mtrE_4
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.931
mtrE_2
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.922
mtrE_1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.919
lolD
Lipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner.
 
0.914
OSI13340.1
Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.905
OSI12643.1
Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.904
Your Current Organism:
Neisseria canis
NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6
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