gmk protein (Neisseria canis) - STRING interaction network

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Score

gmk

Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)

Predicted Functional Partners:

guaA

0.989

apt

0.985

ndk

0.974

spoT

0.972

nrdA

0.965

nrdB

0.962

rpoZ

0.957

hpt

0.949

pykA

0.944

dgk

0.942

Your Current Organism:

Neisseria canis

NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apt	dgk	BWD07_01290	BWD07_03015	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.485
apt	gmk	BWD07_01290	BWD07_01295	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.985
apt	guaA	BWD07_01290	BWD07_03245	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.997
apt	hpt	BWD07_01290	BWD07_05655	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Hypoxanthine-guanine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.950
apt	rpoZ	BWD07_01290	BWD07_01300	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.465
apt	spoT	BWD07_01290	BWD07_01305	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.437
dgk	apt	BWD07_03015	BWD07_01290	Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.485
dgk	gmk	BWD07_03015	BWD07_01295	Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.942
dgk	guaA	BWD07_03015	BWD07_03245	Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.405
dgk	hpt	BWD07_03015	BWD07_05655	Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypoxanthine-guanine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.497
gmk	apt	BWD07_01295	BWD07_01290	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.985
gmk	dgk	BWD07_01295	BWD07_03015	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.942
gmk	guaA	BWD07_01295	BWD07_03245	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.989
gmk	hpt	BWD07_01295	BWD07_05655	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine-guanine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.949
gmk	ndk	BWD07_01295	BWD07_03320	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.974
gmk	nrdA	BWD07_01295	BWD07_03275	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.965
gmk	nrdB	BWD07_01295	BWD07_10075	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.962
gmk	pykA	BWD07_01295	BWD07_09750	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family.	0.944
gmk	rpoZ	BWD07_01295	BWD07_01300	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.957
gmk	spoT	BWD07_01295	BWD07_01305	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.972