Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dipZProtein-disulfide reductase DsbD; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (595 aa)    
Predicted Functional Partners:
msrAB
Trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
  
 
 0.996
dsbC
Thiol:disulfide interchange protein; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
  
 
 0.883
tlpA
Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.870
OSI12993.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.787
dsbB
Disulfide bond formation protein B; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.639
dsbA_1
Disulfide bond formation protein DsbA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.528
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
      
 0.454
OSI13065.1
Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.441
dsbA_2
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.435
hemD
Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
     0.435
Your Current Organism:
Neisseria canis
NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6
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