walK protein (Neisseria canis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Neisseria canis

NCBI taxonomy Id: 493
Other names: ATCC 14687, CIP 103347, LMG 8383, LMG:8383, N. canis, NCTC 10296, strain H 6

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OSI09904.1	OSI12426.1	BWD07_11115	BWD07_05550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.700
OSI09904.1	def	BWD07_11115	BWD07_11130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.744
OSI09904.1	fmt	BWD07_11115	BWD07_11125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	0.807
OSI09904.1	ntrX	BWD07_11115	BWD07_11105	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.881
OSI09904.1	rsmB_1	BWD07_11115	BWD07_11120	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	16S rRNA (cytosine(967)-C(5))-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.	0.810
OSI09904.1	topA	BWD07_11115	BWD07_11150	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.613
OSI09904.1	walK	BWD07_11115	BWD07_11110	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.910
OSI12426.1	OSI09904.1	BWD07_05550	BWD07_11115	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.700
OSI12426.1	walK	BWD07_05550	BWD07_11110	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.611
OSI13142.1	walK	BWD07_02145	BWD07_11110	FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.572
OSI13344.1	walK	BWD07_00055	BWD07_11110	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.572
comL	walK	BWD07_06475	BWD07_11110	Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.559
def	OSI09904.1	BWD07_11130	BWD07_11115	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.744
def	fmt	BWD07_11130	BWD07_11125	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	0.970
def	ntrX	BWD07_11130	BWD07_11105	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.725
def	rsmB_1	BWD07_11130	BWD07_11120	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	16S rRNA (cytosine(967)-C(5))-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.	0.762
def	topA	BWD07_11130	BWD07_11150	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.633
def	walK	BWD07_11130	BWD07_11110	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.744
fmt	OSI09904.1	BWD07_11125	BWD07_11115	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.807
fmt	def	BWD07_11125	BWD07_11130	methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.	0.970