node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA12 | RPC19 | YJR063W | YNL113W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | 0.999 |
RPA12 | RRN11 | YJR063W | YML043C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | 0.956 |
RPA12 | RRN3 | YJR063W | YKL125W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family | 0.989 |
RPA12 | RRN6 | YJR063W | YBL014C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | 0.931 |
RPA12 | RRN7 | YJR063W | YJL025W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family | 0.980 |
RPA12 | RRN9 | YJR063W | YMR270C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | RNA polymerase I-specific transcription initiation factor RRN9; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | 0.695 |
RPA12 | SPT15 | YJR063W | YER148W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP | 0.867 |
RPA12 | UAF30 | YJR063W | YOR295W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication | 0.567 |
RPC19 | RPA12 | YNL113W | YJR063W | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family | 0.999 |
RPC19 | RRN11 | YNL113W | YML043C | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | 0.937 |
RPC19 | RRN3 | YNL113W | YKL125W | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family | 0.991 |
RPC19 | RRN6 | YNL113W | YBL014C | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | 0.963 |
RPC19 | RRN7 | YNL113W | YJL025W | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family | 0.939 |
RPC19 | SPT15 | YNL113W | YER148W | Dna-directed rna polymerases i and iii subunit rpac2; RNA polymerase subunit AC19; common to RNA polymerases I and III | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP | 0.964 |
RRN10 | RRN11 | YBL025W | YML043C | Rna polymerase i-specific transcription initiation factor rrn10; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | 0.988 |
RRN10 | RRN3 | YBL025W | YKL125W | Rna polymerase i-specific transcription initiation factor rrn10; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family | 0.780 |
RRN10 | RRN5 | YBL025W | YLR141W | Rna polymerase i-specific transcription initiation factor rrn10; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | Rna polymerase i-specific transcription initiation factor rrn5; Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p | 0.999 |
RRN10 | RRN6 | YBL025W | YBL014C | Rna polymerase i-specific transcription initiation factor rrn10; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p | 0.988 |
RRN10 | RRN7 | YBL025W | YJL025W | Rna polymerase i-specific transcription initiation factor rrn10; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family | 0.991 |
RRN10 | RRN9 | YBL025W | YMR270C | Rna polymerase i-specific transcription initiation factor rrn10; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | RNA polymerase I-specific transcription initiation factor RRN9; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I | 0.999 |