node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GCD10 | GCD14 | YNL062C | YJL125C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | 0.999 |
GCD10 | NCL1 | YNL062C | YBL024W | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | Multisite-specific tRNA:(cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120. | 0.912 |
GCD10 | NOC2 | YNL062C | YOR206W | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | Nucleolar complex protein 2; Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit. | 0.628 |
GCD10 | PUS7 | YNL062C | YOR243C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria; Belongs to the pseudouridine synthase TruD family. | 0.786 |
GCD10 | TRM1 | YNL062C | YDR120C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial; tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce modified base N2,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body (SPB) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB. | 0.919 |
GCD10 | TRM11 | YNL062C | YOL124C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family. | 0.988 |
GCD10 | TRM7 | YNL062C | YBR061C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. | 0.949 |
GCD10 | TRM8 | YNL062C | YDL201W | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p. | 0.997 |
GCD10 | TRM82 | YNL062C | YDR165W | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism. | 0.995 |
GCD10 | UTP21 | YNL062C | YLR409C | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | U3 small nucleolar RNA-associated protein 21; Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome. | 0.608 |
GCD14 | GCD10 | YJL125C | YNL062C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression. | 0.999 |
GCD14 | NCL1 | YJL125C | YBL024W | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | Multisite-specific tRNA:(cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120. | 0.904 |
GCD14 | NOC2 | YJL125C | YOR206W | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | Nucleolar complex protein 2; Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit. | 0.706 |
GCD14 | PUS7 | YJL125C | YOR243C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria; Belongs to the pseudouridine synthase TruD family. | 0.565 |
GCD14 | TRM1 | YJL125C | YDR120C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial; tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce modified base N2,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body (SPB) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB. | 0.860 |
GCD14 | TRM11 | YJL125C | YOL124C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family. | 0.990 |
GCD14 | TRM7 | YJL125C | YBR061C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily. | 0.941 |
GCD14 | TRM8 | YJL125C | YDL201W | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p. | 0.998 |
GCD14 | TRM82 | YJL125C | YDR165W | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism. | 0.998 |
GCD14 | UTP21 | YJL125C | YLR409C | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. | U3 small nucleolar RNA-associated protein 21; Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome. | 0.626 |