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SEF1 protein (Saccharomyces cerevisiae) - STRING interaction network
"SEF1" - Putative transcription factor, has homolog in Kluyveromyces lactis in Saccharomyces cerevisiae
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second shell of interactors
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SEF1Putative transcription factor, has homolog in Kluyveromyces lactis; Putative transcription factor that seems to be involved in the sporulation process. Suppresses the lethal phenotype of RPM2 deletion (1148 aa)    
Predicted Functional Partners:
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus; Ribonuclease P generates mature tRNA molecules by cleaving their 5’-ends (1202 aa)
       
 
  0.663
UPC2
Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion; Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5’-TCGTTYAG-3’ present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory e [...] (913 aa)
           
  0.546
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene (919 aa)
           
  0.540
RDS3
Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance; Required for pre-mRNA splicing. Involved in regulation of drug sensitivity and may play a role in multidrug resistance (107 aa)
           
  0.485
YKL222C
Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine (705 aa)
           
  0.482
TBS1
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Involved in tolerance to thiabendazole (1094 aa)
           
  0.470
URC2
Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism; Probable transcriptional activator involved in uracil catabolism (772 aa)
           
  0.451
PDR1
Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; Positive regulator of proteins involved in permeability. PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5 (1068 aa)
           
  0.449
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5’-phosphate (DARP), formate and pyrophosphate (345 aa)
           
  0.443
SSN3
Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the h [...] (555 aa)
       
 
  0.443
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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