node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG29 | SFT2 | YPL166W | YBL102W | Autophagy-related protein 29; Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; Belongs to the ATG29 family. | Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5; Belongs to the SFT2 family. | 0.714 |
COG6 | GOS1 | YNL041C | YHL031C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | 0.901 |
COG6 | GOT1 | YNL041C | YMR292W | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition. | 0.723 |
COG6 | RUD3 | YNL041C | YOR216C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | GRIP domain-containing protein RUD3; Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1. | 0.604 |
COG6 | SEC22 | YNL041C | YLR268W | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog. | 0.662 |
COG6 | SED5 | YNL041C | YLR026C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Integral membrane protein SED5; cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins. | 0.873 |
COG6 | SFT2 | YNL041C | YBL102W | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5; Belongs to the SFT2 family. | 0.731 |
COG6 | YKT6 | YNL041C | YKL196C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Synaptobrevin homolog YKT6; Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus; human homolog YKT6 can complement yeast ykt6 mutant; Belongs to the synaptobrevin family. | 0.747 |
COG6 | YPT6 | YNL041C | YLR262C | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | GTP-binding protein YPT6; Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6. | 0.894 |
GOS1 | COG6 | YHL031C | YNL041C | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | 0.901 |
GOS1 | RUD3 | YHL031C | YOR216C | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | GRIP domain-containing protein RUD3; Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1. | 0.574 |
GOS1 | SEC22 | YHL031C | YLR268W | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog. | 0.999 |
GOS1 | SED5 | YHL031C | YLR026C | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | Integral membrane protein SED5; cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins. | 0.999 |
GOS1 | SFT1 | YHL031C | YKL006C-A | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment. | 0.999 |
GOS1 | SFT2 | YHL031C | YBL102W | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5; Belongs to the SFT2 family. | 0.778 |
GOS1 | YKT6 | YHL031C | YKL196C | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | Synaptobrevin homolog YKT6; Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus; human homolog YKT6 can complement yeast ykt6 mutant; Belongs to the synaptobrevin family. | 0.999 |
GOS1 | YPT6 | YHL031C | YLR262C | Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28. | GTP-binding protein YPT6; Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6. | 0.780 |
GOT1 | COG6 | YMR292W | YNL041C | Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition. | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | 0.723 |
GOT1 | RUD3 | YMR292W | YOR216C | Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition. | GRIP domain-containing protein RUD3; Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1. | 0.520 |
GOT1 | SEC22 | YMR292W | YLR268W | Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition. | R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog. | 0.680 |