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POA1 protein (Saccharomyces cerevisiae) - STRING interaction network
"POA1" - Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite in Saccharomyces cerevisiae
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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POA1Phosphatase that is highly specific for ADP-ribose 1’’-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing; Highly specific phosphatase involved in the metabolism of ADP-ribose 1’’-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose (177 aa)    
Predicted Functional Partners:
YMR087W
Putative ADP-ribose-1’’-monophosphatase; converts ADP-ribose-1’’-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain; Highly specific phosphatase involved in the metabolism of ADP-ribose 1’’-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. + phosphate (284 aa)
           
  0.697
YBR013C
Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein (129 aa)
           
  0.636
SNM1
Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP; Essential component of the MRP ribonucleoprotein endoribonuclease that cleaves mitochondrial primer RNA sequences (198 aa)
           
  0.580
RMA1
Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Conversion of folates to polyglutamate derivatives (430 aa)
         
  0.542
MRM1
Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; S-adenosyl-L-methionine-dependent 2’-O-ribose methyltransferase that catalyzes the formation of 2’-O- methylguanosine at position 2270 (Gm2270) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This modification seems to be important for the normal accumulation of the mitochondrial large ribosomal subunit (412 aa)
       
      0.507
YMR103C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (120 aa)
           
  0.505
YDR476C
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene (224 aa)
           
  0.489
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; Probable phosphomutase that may have a function related to the manipulation of phosphate groups on carbohydrates. Reduces trehalose-6-phosphate levels when overexpressed in TPS2-deleted cells. Reduces 5’-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR) levels, a metabolic intermediate at the crossroads between AMP and histidine biosynthesis pathways, when [...] (295 aa)
           
  0.487
JIP4
Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence (876 aa)
           
  0.445
DIA3
Protein of unknown function, involved in invasive and pseudohyphal growth (468 aa)
           
  0.441
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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