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RIB7 protein (Saccharomyces cerevisiae) - STRING interaction network
"RIB7" - Diaminohydroxyphoshoribosylaminopyrimidine deaminase in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RIB7Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway; Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino- 6-ribosylamino-4(3H)-pyrimidinone 5’-phosphate, yielding 2,5- diamino-6-ribitylamino-4(3H)-pyrimidinone 5’-phosphate (244 aa)    
Predicted Functional Partners:
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5’-phosphate (DARP), formate and pyrophosphate (345 aa)
  0.999
RIB2
Bifunctional enzyme with DRAP deaminase and tRNA-pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; Responsible for synthesis of pseudouridine from uracil- 32 in cytoplasmic transfer RNAs (591 aa)
   
 
  0.994
RIB3
3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (208 aa)
 
  0.978
RIB5
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway; Catalyzes the dismutation of two molecules of 6,7- dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil (238 aa)
 
  0.949
RIB4
Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (169 aa)
   
  0.943
FCY1
Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4 (158 aa)
       
  0.722
TAD3
Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; Deaminates adenosine-34 to inosine in many tRNAs (322 aa)
   
 
  0.715
ARO1
Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (1588 aa)
         
  0.694
DFR1
Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) (211 aa)
         
  0.683
FOL2
GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway; GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid (243 aa)
   
 
  0.679
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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