node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMN1 | ICS2 | YBR158W | YBR157C | Antagonist of mitotic exit network protein 1; Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); Belongs to the AMN1 family | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | 0.710 |
AMN1 | SLI15 | YBR158W | YBR156C | Antagonist of mitotic exit network protein 1; Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); Belongs to the AMN1 family | Inner centromere protein-related protein SLI15; Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p | 0.483 |
ECM9 | ICS2 | YKR004C | YBR157C | Protein ecm9; May be involved in cell wall organization and biogenesis | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | 0.695 |
ECM9 | PIR5 | YKR004C | YJL160C | Protein ecm9; May be involved in cell wall organization and biogenesis | Cell wall protein PIR5; Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication | 0.744 |
ECM9 | PTK1 | YKR004C | YKL198C | Protein ecm9; May be involved in cell wall organization and biogenesis | Serine/threonine-protein kinase PTK1/STK1; Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication | 0.453 |
ECM9 | RRT8 | YKR004C | YOL048C | Protein ecm9; May be involved in cell wall organization and biogenesis | Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress | 0.748 |
ECM9 | SKG1 | YKR004C | YKR100C | Protein ecm9; May be involved in cell wall organization and biogenesis | Suppressor of lethality of KEX2 GAS1 double null mutant protein 1; Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication | 0.780 |
ECM9 | YKL033W-A | YKR004C | YKL033W-A | Protein ecm9; May be involved in cell wall organization and biogenesis | Putative protein of unknown function; similar to uncharacterized proteins from other fungi; Belongs to the HAD-like hydrolase superfamily | 0.779 |
ICS2 | AMN1 | YBR157C | YBR158W | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Antagonist of mitotic exit network protein 1; Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); Belongs to the AMN1 family | 0.710 |
ICS2 | ECM9 | YBR157C | YKR004C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Protein ecm9; May be involved in cell wall organization and biogenesis | 0.695 |
ICS2 | IMA3 | YBR157C | YIL172C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4 | 0.706 |
ICS2 | PIR5 | YBR157C | YJL160C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Cell wall protein PIR5; Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication | 0.750 |
ICS2 | PTK1 | YBR157C | YKL198C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Serine/threonine-protein kinase PTK1/STK1; Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication | 0.699 |
ICS2 | RRT8 | YBR157C | YOL048C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress | 0.654 |
ICS2 | SKG1 | YBR157C | YKR100C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Suppressor of lethality of KEX2 GAS1 double null mutant protein 1; Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication | 0.712 |
ICS2 | SLI15 | YBR157C | YBR156C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Inner centromere protein-related protein SLI15; Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p | 0.692 |
ICS2 | YKL033W-A | YBR157C | YKL033W-A | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Putative protein of unknown function; similar to uncharacterized proteins from other fungi; Belongs to the HAD-like hydrolase superfamily | 0.712 |
ICS2 | YNL095C | YBR157C | YNL095C | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | Auxin efflux carrier family protein; Uncharacterized transporter YNL095C; Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication | 0.749 |
IMA3 | ICS2 | YIL172C | YBR157C | Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4 | Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization | 0.706 |
PIR5 | ECM9 | YJL160C | YKR004C | Cell wall protein PIR5; Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication | Protein ecm9; May be involved in cell wall organization and biogenesis | 0.744 |