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MBA1 protein (Saccharomyces cerevisiae) - STRING interaction network
"MBA1" - Membrane-associated mitochondrial ribosome receptor in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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MBA1Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane; Mitochondrial inner membrane-associated mitoribosome receptor that spatially aligns the mitoribosome exit tunnel with the membrane insertion machinery and allows cotranslational protein membrane insertion (278 aa)    
Predicted Functional Partners:
YTA12
Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non- assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (825 aa)
       
 
  0.965
AFG3
Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non- assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (761 aa)
       
 
  0.965
OXA1
Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals; Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear- encoded proteins from the matrix into the inner membrane. Links mitoribosomes with the inner membrane (PubMed-22904327). Forms pores capable of accommodating translocating protein segments (PubMed-22829595). Essential for the activity and [...] (402 aa)
     
 
  0.916
COX18
Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space (316 aa)
     
   
  0.802
PNT1
Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine; Probably involved in mitochondrial export. Confers resistance to the anti-pneumocystis carinii drug pentamidine. May act by the removal of pentamidine, or its damage targets, from the matrix by an active-transport mechanism (423 aa)
       
 
  0.732
MSS2
Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; Required to stabilize mitochondrial cytochrome C oxidase subunit 2 (COX2) and to translocate the C-terminal domain of COX2 through the inner membrane (351 aa)
       
 
  0.732
MDM38
Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome; Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation (PubMed-11907266, PubMed-15138253). With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane (PubMed-20427570) (573 aa)
       
 
  0.729
STE50
Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; Involved in growth arrest during conjugation. May interact with the G protein alpha subunit (346 aa)
       
      0.688
MRPL36
Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region; Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions (177 aa)
     
      0.634
MRPL20
Mitochondrial ribosomal protein of the large subunit (195 aa)
     
      0.611
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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