| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DUR1,2 | HOM3 | YBR208C | YER052C | Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Hydrolysis of urea to ammonia and CO(2) | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis | 0.494 |
| DUR1,2 | NHA1 | YBR208C | YLR138W | Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Hydrolysis of urea to ammonia and CO(2) | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | 0.404 |
| DUR1,2 | VHC1 | YBR208C | YBR235W | Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Hydrolysis of urea to ammonia and CO(2) | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation | 0.750 |
| ENA1 | NHA1 | YDR040C | YLR138W | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3 | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | 0.973 |
| ENA1 | TRK1 | YDR040C | YJL129C | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3 | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; This protein is required for high-affinity potassium transport | 0.777 |
| ENA1 | TRK2 | YDR040C | YKR050W | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3 | Component of the Trk1p-Trk2p potassium transport system; This protein is required for low-affinity potassium transport | 0.766 |
| ENA1 | VHC1 | YDR040C | YBR235W | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3 | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation | 0.723 |
| HOM3 | DUR1,2 | YER052C | YBR208C | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis | Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Hydrolysis of urea to ammonia and CO(2) | 0.494 |
| HOM3 | HOM6 | YER052C | YJR139C | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis | Homoserine dehydrogenase (L-homoserine-NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions | 0.999 |
| HOM3 | VHC1 | YER052C | YBR235W | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation | 0.614 |
| HOM6 | HOM3 | YJR139C | YER052C | Homoserine dehydrogenase (L-homoserine-NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions | Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis | 0.999 |
| HOM6 | VHC1 | YJR139C | YBR235W | Homoserine dehydrogenase (L-homoserine-NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation | 0.588 |
| NHA1 | DUR1,2 | YLR138W | YBR208C | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Hydrolysis of urea to ammonia and CO(2) | 0.404 |
| NHA1 | ENA1 | YLR138W | YDR040C | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3 | 0.973 |
| NHA1 | TRK1 | YLR138W | YJL129C | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; This protein is required for high-affinity potassium transport | 0.957 |
| NHA1 | TRK2 | YLR138W | YKR050W | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | Component of the Trk1p-Trk2p potassium transport system; This protein is required for low-affinity potassium transport | 0.932 |
| NHA1 | VHC1 | YLR138W | YBR235W | Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH; Sodium export from cell, takes up external protons in exchange for internal sodium ions | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation | 0.760 |
| OR26.19 | VHC1 | YOR029W | YBR235W | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data | Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene; Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation | 0.794 |
| OR26.19 | YBR232C | YOR029W | YBR232C | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data | 0.892 |
| TRK1 | ENA1 | YJL129C | YDR040C | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; This protein is required for high-affinity potassium transport | P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3 | 0.777 |
